BRIEF

on The Vanguard Group, Inc. (isin : US12572Q1058)

The Vanguard Group's Interests in Mural Oncology plc

The Vanguard Group, Inc. has disclosed its interests and dealings in Mural Oncology plc under the Irish Takeover Panel rules. As of September 23, 2025, Vanguard holds 646,568 ordinary shares of Mural Oncology, representing a 3.74% stake.

The disclosure details the purchase of 32 ordinary shares and the sale of 18,256 shares, both at a price of 2.09 USD per unit. No cash-settled or stock-settled derivative transactions have been reported. Additionally, there are no arrangements related to options or derivatives associated with Mural Oncology's securities.

No indemnity, option arrangements, or inducement agreements have been entered into by Vanguard with any party to the offer, and there are no understandings regarding the voting rights of any securities.

R. E.

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